. 2015 Aug 5;9:4319–4328. doi: 10.2147/DDDT.S83055

Table 5.

In vivo pharmacokinetic parameters

Species	Dose (mg/kg)	Route	T_max (h)	AUC_0→t (ng h/mL)	CL^P (L/h/kg)^a	CL^B (L/h/kg)^b	V_ss^P (L/kg)^a	V_ss^B (L/kg)^b	T_1/2 (h)	F
Mouse	10	IV	0.25	6,636	1.50	1.78	1.51	1.79	0.80
	50	PO		17,004					4.29	51
Rat	2	IV	1.00	1,877±242	1.06±0.14	0.83±0.11	1.75±0.29	1.38±0.23	1.30±0.30
	10	PO		6,406±1,556					4.81±0.90	68±17
Dog	2	IV	2.00	1,007±18	1.87±0.07	2.23±0.08	4.65±0.13	5.54±0.15	2.33±0.67
	50	PO		5,178±3,923					6.71±5.44	21±16
Monkey	2	IV	6	2,031±326	0.49±0.09	–	3.57±0.71	–	6.82±0.90
	5	PO		2,578±1,615					4.56±0.50	25±15

Notes:

CL^P and V_ss^P were derived from analysis of the plasma concentration–time data.

CL^B (L/h/kg) and V_ss^B (L/kg) were calculated using the plasma parameter and blood/plasma values from in vitro studies.

Abbreviations: h, hour; IV, intravenous; CL, clearance.