. Author manuscript; available in PMC: 2015 Aug 11.

Published in final edited form as: Stat Med. 2012 Mar 16;31(18):1944–1960. doi: 10.1002/sim.5346

Table II.

Power and expected study duration of the three designs in Table I.

Case	π₀	π₁	e^α	e^β	e^γ	d(π, ξ)	Phase II₁ and III			Phase II₂ and III			Phase II–III
Case	π₀	π₁	e^α	e^β	e^γ	d(π, ξ)	pr(RS)	pr(R)	E(T)	pr(RS)	pr(R)	E(T)	pr(RS)	pr(R)	pr(R₁)	E(T)
1	0.3	0.6	1.00	0.75	1.00	0.25	0.734	0.895	4.67	0.699	0.859	5.19	0.855	0.998	0.638	5.58
2	0.3	0.6	0.75	0.79	1.00	0.25	0.797	0.913	4.68	0.711	0.851	5.13	0.883	0.998	0.665	5.44
3	0.3	0.6	0.50	0.86	1.00	0.25	0.823	0.904	4.46	0.872	0.869	5.09	0.895	0.996	0.628	5.35
4	0.3	0.6	0.17	1.00	1.00	0.25	0.885	0.910	4.09	0.817	0.846	4.70	0.895	0.999	0.664	5.11
5	0.3	0.6	0.75	1.00	0.61	0.25	0.849	0.905	4.42	0.788	0.854	4.93	0.867	0.997	0.661	5.46
6	0.3	0.6	0.50	1.00	0.67	0.25	0.891	0.922	4.36	0.814	0.851	4.80	0.897	0.999	0.641	5.34
7	0.3	0.5	0.75	1.00	0.47	0.25	0.616	0.639	3.10	0.544	0.570	3.53	0.789	0.889	0.274	5.06
8	0.3	0.5	1.00	0.75	1.00	0.25	0.527	0.647	3.43	0.447	0.557	3.72	0.759	0.875	0.299	5.22
9	0.2	0.5	1.00	0.75	1.00	0.25	0.550	0.665	3.54	0.691	0.882	5.30	0.855	0.998	0.638	5.51