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. 2015 Aug 11;10(8):e0134648. doi: 10.1371/journal.pone.0134648

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© 2015 Ali et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 7 — Effect of different doses of galantamine (Galan 2.5, 5 & 10 mg/kg), vildagliptin (Vilda 3, 10 & 30 mg/kg) and their combination (Galan 5 + Vilda 30) on hepatic (A) and muscular (B) transcription activation of Nrf2 (nuclear factor-erythroid-2-related factor 2), total antioxidant capacity (C, D) and malondialdehyde (MDA) content (E, F), respectively, in n-STZ diabetic rats. Drugs were gavaged orally for four weeks. Values are means of 10 rats ± S.E.M as compared with normal control (*), diabetic control (#), Galan5 (η), Galan10 (ɸ) and Vilda30 (Ψ)-treated groups (one-way ANOVA followed by Tukey post hoc test) at P< 0.05. (a) Additive and (b) synergistic interactions when Galan5 and Vilda30 were combined using Factorial Design.