Fig 7. Isometric tension in mouse, rat, and human.

Shown in panel A are the tension transients described in Table 4. The last 500 ms of the human tension transients are not shown, as force is very low throughout. These results were driven by fixed calcium transients shown in panel B, based on recent data in mouse [66] and rat (see S1 Text [67, 68]) measured at 37°C and 6 Hz, and data from Coppini et al. [69] (see S1 Text [70]). Two sets of results are shown, corresponding to a constant crossbridge unbinding rate (q = 1 in Eq 22) and a crossbridge unbinding rate that is variable, modified by the average difference in free energy for the tropomyosin deformation (q = 0.5 in Eq 22)