Table 2. Model predictions for shifts in pCa50 after changes in crossbridge affinity.
| Experiment | Blebbistatin [16] | dATP [55] |
|---|---|---|
| Experimental conditions | Skinned, room temp., mouse | Skinned, 15°C, rat |
| Experimental max. force | -73% | +31% |
| Experimental ΔpCa50 | -0.34 | +0.13 |
| Model conditions | Both models represent intact muscle, 37°C, mouse | |
| Model max. force (fitted) | -73.6% | +30.9% |
| Model ΔpCa50 | -0.248 | +0.117 |
Predictions of changes in calcium sensitivity (ΔpCa50) when fitting crossbridge affinity in the model to reproduce changes in maximal force shown experimentally. See Fig 6 for full traces.