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. 2015 Aug 11;11(8):e1004376. doi: 10.1371/journal.pcbi.1004376

Table 3. List of model parameters.

Parameter Value Determined based on
K DA 10−3 Cooperativity, effective competitive binding
K DI 4 ⋅ 10−3 Cooperativity, effective competitive binding
K DC 5.9 μM Required Ca50, literature data, previous modelling [19, 37]
K DM 2 Duty ratio in fully activated muscle
k A- 10/ms High enough to not be rate-limiting
k I- 10/ms High enough to not be rate-limiting
k C+ 0.5/ms Fitting to TPT, RT, Maximum twitch force
k M- 0.5/ms Fitting to TPT, RT, Maximum twitch force
γ 2 Cooperativity n 2 ≈ 8

Shown here are all model parameters for the mouse model with the method used for parametrization.