Table 3. List of model parameters.
Parameter | Value | Determined based on |
---|---|---|
K DA | 10−3 | Cooperativity, effective competitive binding |
K DI | 4 ⋅ 10−3 | Cooperativity, effective competitive binding |
K DC | 5.9 μM | Required Ca50, literature data, previous modelling [19, 37] |
K DM | 2 | Duty ratio in fully activated muscle |
k A- | 10/ms | High enough to not be rate-limiting |
k I- | 10/ms | High enough to not be rate-limiting |
k C+ | 0.5/ms | Fitting to TPT, RT, Maximum twitch force |
k M- | 0.5/ms | Fitting to TPT, RT, Maximum twitch force |
γ | 2 | Cooperativity n 2 ≈ 8 |
Shown here are all model parameters for the mouse model with the method used for parametrization.