Table 2. ORs and 95% CIs of DNMT3b polymorphisms for gastric atrophy and gastric cancer.
| Genotype | Controls(%) n = 961 | GC(%) n = 447 | OR(95%CI) a | P value | GA(%) n = 111 | OR(95%CI) a | P value |
|---|---|---|---|---|---|---|---|
| rs6119954 | |||||||
| GG | 45.1 | 44.8 | Reference | 52.3 | Reference | ||
| GA | 46.3 | 44.6 | 1.00(0.76–1.31) | 1.00 | 38.7 | 0.70(0.46–1.07) | 0.10 |
| AA | 8.6 | 10.6 | 1.37(0.88–2.13) | 0.17 | 9.0 | 0.89(0.43–1.83) | 0.75 |
| rs1569686 | |||||||
| TT | 83.4 | 80.5 | Reference | 82.9 | Reference | ||
| TG | 15.6 | 18.3 | 1.14(0.82–1.60) | 0.44 | 16.2 | 0.99(0.58–1.70) | 0.97 |
| GG | 1.0 | 1.1 | 1.33(0.41–4.31) | 0.64 | 0.9 | 0.92(0.11–7.56) | 0.94 |
| rs4911107 | |||||||
| AA | 83.2 | 80.5 | Reference | 82.9 | Reference | ||
| AG | 15.7 | 18.3 | 0.86(0.26–2.88) | 0.81 | 16.2 | 1.07(0.12–9.14) | 0.95 |
| GG | 1.1 | 1.1 | 0.76(0.23–2.46) | 0.64 | 0.9 | 1.08(0.13–8.86) | 0.94 |
| rs4911259 | |||||||
| GG | 83.1 | 80.3 | Reference | 82.9 | Reference | ||
| GT | 15.8 | 18.6 | 0.86(0.26–2.89) | 0.81 | 16.2 | 1.06(0.12–9.04) | 0.96 |
| TT | 1.1 | 1.1 | 0.76(0.23–2.45) | 0.64 | 0.9 | 1.09(0.13–8.88) | 0.94 |
| rs8118663 | |||||||
| AA | 32.7 | 28.2 | Reference | 34.2 | Reference | ||
| AG | 49.2 | 52.1 | 1.28(0.95–1.72) | 0.10 | 50.5 | 0.96(0.62–1.50) | 0.96 |
| GG | 18.1 | 19.7 | 1.32(0.91–1.91) | 0.15 | 15.3 | 0.76(0.41–1.39) | 0.37 |
| Haplotype b | |||||||
| GTA | 56.5 | 54.0 | Reference | 59.4 | Reference | ||
| ATG | 31.1 | 32.5 | 1.16(0.93–1.44) | 0.18 | 28.4 | 0.88(0.63–1.21) | 0.43 |
| GGG | 8.8 | 10.4 | 1.25(0.90–1.72) | 0.18 | 9.0 | 0.96(0.58–1.60) | 0.88 |
| GTG | 2.9 | 2.7 | 1.04(0.57–1.89) | 0.90 | 3.2 | 1.00(0.42–2.37) | 1.00 |
aORs for each genotype and haplotype were calculated adjusting for age, sex and H.pylori infection in logistic regression model.
bThe haplotype was lined with rs6119954, rs1569686 and rs8118663 and displayed as percentage.