Table 4. Risk factors for 90-day mortality in mechanically ventilated ICU patients.
| Explanatory variable | Survivors (n = 115) | Dead (n = 103) | Unadjusted HR (95% CI) | P-value | Adjusted HR (95% CI)* | Adjusted P-value* |
|---|---|---|---|---|---|---|
| Age (years) | 36.0 ± 16.1 | 44.2 ± 17.9 | 1.02 (1.01–1.03) | 0.001 | 1.01 (1.00–1.02) | 0.156 |
| APACHE II score | ||||||
| Quartile 1 | 49/58 (84%) | 9/58 (16%) | 1.00 † | — † | 1.00 † | — † |
| Quartile 2 | 30/56 (54%) | 26/56 (46%) | 3.58 (1.68–7.65) | 0.001 | 2.65 (1.19–5.89) | 0.017 |
| Quartile 3 | 24/50 (48%) | 26/50 (52%) | 4.68 (2.19–9.99) | < 0.001 | 2.98 (1.24–7.15) | 0.014 |
| Quartile 4 | 12/54 (22%) | 42/54 (78%) | 9.04 (4.39–18.64) | < 0.001 | 5.78 (2.45–13.60) | < 0.001 |
| Organ failure—baseline | 67 (58%) | 84 (81%) | 2.52 (1.53–4.16) | < 0.001 | 1.13 (0.62–2.05) | 0.688 |
| Organ failure—new-onset | 20 (17%) | 63 (61%) | 3.55 (2.38–5.30) | < 0.001 | 2.98 (1.94–4.56) | < 0.001 |
| Serum albumin (g/dL) | 3.2 ± 0.5 | 2.8 ± 0.6 | 0.45 (0.33–0.61) | < 0.001 | 0.82 (0.57–1.19) | 0.303 |
| Diabetes | 12 (10%) | 25 (24%) | 1.81 (1.15–2.85) | 0.010 | 0.78 (0.46–1.33) | 0.365 |
| Hypertension | 7 (6%) | 18 (17%) | 1.89 (1.13–3.14) | 0.015 | 0.98 (0.52–1.87) | 0.956 |
APACHE II = Acute physiology and chronic health evaluation II
*Complete data set for multivariable analysis was available for 214 patients including 101 deaths;
†Referent quartile