Figure 2.
Arteriolar responses to α2R activation at five arteriolar orders
Top: percentage change in arteriolar constriction (from baseline) for five arteriolar orders (1A through 5A, n = 6–22 arterioles) at increasing logarithmic concentrations (m) of UK 14304. Data presented as mean the ± SEM. #Statistically different from 2A; †statistically different from 3A (both P < 0.05). Constriction responses to peak concentrations of UK 14304 were blocked by yohimbine (% indicates difference between responses with and without antagonist at UK 14304 10−5 m, P < 0.05) for all orders. Bottom: normalized constriction responses fit to sigmoids. LogEC50 values are reported and were similar across arteriolar orders.