Table 6.
Representative metabolic entities altered (< 2-fold) by GDM in the livers of 15-week-old male offspring (n = 12) identified by LC-QTOF-MS
| Fold change | |||||
|---|---|---|---|---|---|
| Entity | Formula | [M + H]+ | Lean-LF vs. Lean-HFS | Lean-LF vs. GDM-LF | Lean-LF vs. GDM-HFS |
| Ceramide | |||||
| Ceramide (d18:2/16:0) | C34H65NO3 | 536.5052 | +1.4 | +1.7 | +160.9 |
| Ceramide (d18:0/16:0) | C34H69NO3 | 540.5392 | +2.8 | +55.6 | +73.5 |
| Diacylglycerol (DG) | |||||
| DG (18:1/18:2/0:0) | C39H70O5 | 619.5312 | +2.8 | +35.7 | +35.7 |
| DG (18:1/18:3/0:0) | C39H68O5 | 617.5157 | +2.7 | +90 | +90 |
| DG (16:0/22:1/0:0) | C41H78O5 | 651.5922 | +4.1 | +57.7 | +57 |
| DG (18:0/18:1/0:0) | C39H74O5 | 623.0018 | +2.9 | +9.2 | +103.9 |
| DG (16:0/16:1/0:0) | C35H66O5 | 567.4983 | +3.2 | +1.5 | +613 |
| Phosphatidyl-ethanolamine (PE) | |||||
| PE (18:1/18:3) | C41H74NO8P | 739.5147 | +2.0 | −2.6 | −94.8 |
| PE (18:3/20:3) | C43H74NO8P | 764.5251 | −4.9 | −6.5 | −25.4 |
| PE (18:3/20:2) | C43H76NO8P | 766.5400 | +1.7 | −9.6 | −12.5 |
| PE (20:3/20:4) | C45H76NO8P | 790.5385 | +2.6 | −1.1 | −8.5 |
| PE (18:2/18:3) | C41H72NO8P | 738.5095 | −3.6 | −6.2 | −27.3 |
| PE (20:4/20:4) | C45H74NO8P | 788.5243 | −4.3 | −6.3 | −26.8 |
| Phosphatidylserine (PS) | |||||
| PS (18:0/20:2) | C44H82NO10P | 816.5749 | −1.6 | −1.6 | −5.6 |
| PS (18:0/20:3) | C44H80NO10P | 813.5514 | +3.0 | −4.0 | −4.6 |
| Phosphatidylinositol (PI) | |||||
| PI (18:1/20:3) | C47H83O13P | 887.5643 | −1.8 | −3.3 | −24.7 |
| PI (22:2/16:1) | C47H85O13P | 889.5781 | +1.1 | −45.1 | −58.3 |