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. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: Neuroscience. 2015 Jul 4;303:220–228. doi: 10.1016/j.neuroscience.2015.06.060

Figure 5.

Figure 5

Effect of sustained insulin delivery in vivo on insulin receptor (A, C) and GSK3β (B, D) phosphorylation in sciatic nerve (A, B) and hippocampus (C, D) from diabetic rats (close square). Levels of phosphorylation of insulin receptor (A, C) and GSK3β (B, D) after 15 min incubation with varied concentration of insulin (0, 0.1, 1 n M) for tissues from control (close circle), diabetic (close square), diabetic implanted with partial insulin pellet (upright triangle) or full insulin pellet (downward triangle) rats. Data are mean ±sem, n=4–7. *p<0.05, **p<0.01 vs 0 nM insulin by two-way ANOVA followed by Dunnett’s post hoc test, # p<0.05, ##p<0.01 vs diabetic (closed square) at the same time point by two-way ANOVA followed by Tukey’s post hoc test.