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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Trends Pharmacol Sci. 2015 Jun 8;36(8):514–523. doi: 10.1016/j.tips.2015.05.002

Figure 1.

Figure 1

Charged residues of the nAChR in the short intracellular loop between TM1 and TM2 and in the segments of the large intracellular domains closest to the transmembrane domains. Note that histidine, which is marked as positively charged, is borderline between polar and charged, while arginine and lysine are always likely to be positively charged and not as polar as histidine. The positively charged residues are colored blue and underlined. The negatively charged residues are in red italics. Secondary structure as predicted by PsiPred (http://bioinf.cs.ucl.ac.uk/psipred/) is indicated with pink for helices and yellow for beta strands (as in Figure S1). Torpedo marmorata subunits are included with human nAChR and 5HT3A subunits.