Table 2.
Putative association/consensus sites in α7 nAChR
| human | bovine | rat | chick | frog | fish | |
|---|---|---|---|---|---|---|
| ELM analysis | ||||||
| CLV_C14_Caspase3-7 | 1 | |||||
| DEG_APCC_DBOX_1 | 1 | 1 | 1 | 1 | 1 | |
| DEG_Nend_UBRbox_1 | 1 | 1 | ||||
| DEG_Nend_UBRbox_3 | 1 | 1 | 1 | |||
| DEG_SCF_TRCP1_1 | 1 | |||||
| DOC_CKS1_1 | 1 | |||||
| DOC_MAPK_1 | 1 | 1 | 1 | 1 | 1 | |
| DOC_PP2B_2 | ||||||
| DOC_WW_Pin1_4 | 2 | 2 | 2 | 2 | 3 | 2 |
| LIG_14-3-3-2 | 1 | 1 | ||||
| LIG_SH2_STAT5 | 2 | 2 | 2 | 2 | 2 | 2 |
| LIG_SH3_3 | 2 | 1 | 1 | |||
| LIG_TRAF2_1 | 2 | 1 | ||||
| MOD_CK1_1 | 1 | 1 | 1 | 1 | 1 | 5 |
| MOD_CK2_1 | 1 | 1 | 1 | 3 | 1 | 1 |
| MOD_GSK3_1 | 1 | 1 | 1 | 2 | 2 | 4 |
| MOD_NEK2_1 | 1 | |||||
| MOD_NEK2_2 | 1 | 1 | ||||
| MOD_PKA_1 | 1 | 1 | 1 | 1 | 1 | |
| MOD_PKA_2 | 1 | 1 | 1 | 2 | 2 | 1 |
| MOD_PLK | 1 | 1 | 1 | 1 | 1 | |
| MOD_ProDKin_1 | 2 | 2 | 2 | 2 | 3 | 2 |
| TRG_ENDOCYTIC_2 | 1 | 1 | 1 | 1 | 1 | 1 |
| TRG_ER_diArg_1 | 1 | |||||
| TRG_LysEnd_APsAcLL_1 | 1 | 1 | 1 | |||
| TRG_PEX_1 | 1 | 1 | 1 | 1 | 1 | 1 |
CLV_C14_Caspase3-7 (Caspase3 and Caspase7 cleavage site), DEG_APCC_DBOX_1 (destruction motif that binds to the Cdh1 and Cdc20), DEG_Nend_UBRbox_1 (N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins), DEG_Nend_UBRbox_3 (N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins), DEG_SCF_TRCP1_1 (The DSGxxS phospho-dependent degron binds the F box protein of the SCF-betaTrCP1 complex), DOC_CKS1_1 (Phospho-dependent motif that mediates docking of CDK substrates and regulators to cyclin-CDK-bound Cks1), DOC_MAPK_1 (Mitogen-activated protein kinase), DOC_PP2B_2 (Docking motif in calcineurin substrates that binds at the interface of the catalytic CNA and regulatory CNB subunits), DOC_WW_Pin1_4 (The Class IV WW domain interaction motif is recognised primarily by the Pin1 phosphorylation-dependent prolyl isomerase), LIG_14-3-3-2 (Longer mode 2 interacting phospho-motif for 14-3-3 proteins), LIG_SH2_STAT5 (STAT5 Src Homology 2 (SH2) domain binding motif), LIG_SH3_3 (This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity), LIG_TRAF2_1 (Major TRAF2-binding consensus motif), MOD_CK1_1 (CK1 phosphorylation site), MOD_CK2_1 (CK2 phosphorylation site), MOD_GSK3_1 (GSK3 phosphorylation recognition site), MOD_NEK2_1 (NEK2 phosphorylation motif), MOD_NEK2_2 (NEK2 phosphorylation motif), MOD_PKA_1 (cAMP-dependent protein kinase A), MOD_PKA_2 (Secondary preference for PKA-type AGC kinase phosphorylation), MOD_PLK (Site phosphorylated by the Polo-like kinase), MOD_ProDKin_1 (Proline-Directed Kinase (e.g. MAPK) phosphorylation site), TRG_ENDOCYTIC_2 (Adaptor Protein complex binding motif), TRG_ER_diArg_1 (di-Arg ER retention motif), TRG_LysEnd_APsAcLL_1 (Sorting signal directing type I transmembrane proteins), TRG_PEX_1 (peroxisomal import receptor Motif)