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. Author manuscript; available in PMC: 2016 Aug 28.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Jul 10;464(3):698–704. doi: 10.1016/j.bbrc.2015.06.170

Figure 4. Survival plots of sphpa-Tg mice vs. C57BL control mice inoculated i.p. with RML prions.

Figure 4

RML was inoculated (i.p.) into transgenic mice (A, males; B, females) over-expressing a secreted form of human heparanase (sphpa-Tg) vs. control C57BL mice. Mice inoculated i.c. or i.p. with PBS did not show any signs of prion disease >400 days post-inoculation.