Table 1.
Modulation of TAAR 1 on behavioral effects of psychostimulants.
| Behavioral Model | Drug | Species | Treatment | Effect | Reference |
|---|---|---|---|---|---|
| Self-administration | Cocaine | Rats | RO5203648 | Attenuation of cocaine taking | (Revel et al., 2012i) |
| Rats | RO5203648 | Attenuation of context- and drug-induced relapse | (Pei et al., 2014) | ||
| Rats | RO5256390 | Attenuation of context- and drug-induced relapse | (Pei et al., 2014) | ||
| Rats | RO5263397 | Attenuation of cue- and drug-induced reinstatement | (Thorn et al., 2014a) | ||
| Methamphetamine | Rats | RO5263397 | Attenuation of methamphetamine taking | (Jing et al., 2015) | |
| Rats | RO5263397 | Attenuation of cue- and drug-induced reinstatement | (Jing et al., 2015) | ||
| Behavioral sensitization | Cocaine | Rats | RO5263397 | Attenuation of induction and expression of behavioral sensitization | (Thorn et al., 2014a; Thorn et al., 2014h) |
| Methamphetamine | Rats | RO5263397 | Attenuation of expression of behavioral sensitization | (Jing et al., 2015) | |
| CPP | Cocaine | Rats | RO5263397 | Attenuation of expression, but not development of cocaine CPP | (Thorn et al., 2014a) |
| Methamphetamine | Mice | Taar−/− | Magnitude of METH-induced CPP in Taar−/−>WT | (Achat-Mendes et al., 2012e) | |
| Acquisition time of METH-induced CPP: Taar−/−< WT | |||||
| Retention time of METH-induced CPP: Taar−/−> WT | |||||
| No difference in METH-induced reinstatement of CPP | |||||
| Morphine | Mice | Taar−/− | No difference in Magnitude of morphine-induced CPP | (Achat-Mendes et al., 2012e) | |
| Locomotion | d-amphetamine | Mice | Taar 1 Tg | Reduced response to AMPH | (Revel et al., 2012a) |
| d-amphetamine | Mice | RO5073012+ Taar 1 Tg | Enhancement of sensitivity to AMPH | (Revel et al., 2012a) | |
| Mice | RO5073012 | Attenuation of AMPH-induced hyperlocomotion | (Revel et al., 2012a) | ||
| Mice | Taar−/− | Enhancement of sensitivity to AMPH (lower dose) | (Wolinsky et al., 2007) | ||
| Mice | Taar−/− | Enhancement of sensitivity to AMPH | (Lindemann et al., 2008) | ||
| Mice | Taar−/− | AMPH-induced hyperactivity in Taar−/−>WT | (Achat-Mendes et al., 2012e) | ||
| Cocaine | Rats | RO5203648 | Attenuation of cocaine-induced hyperlocomotion | (Revel et al., 2012i) | |
| Mice | RO5203648 | Attenuation of cocaine-induced hyperlocomotion | (Revel et al., 2012i) | ||
| Mice | RO5203648+ DAT−/− | Attenuation of hyperlocomotion | (Revel et al., 2012i) | ||
| Mice | RO5203648+ DAT−/−/ Taar−/− | No effect on hyperlocomotion | (Revel et al., 2012i) | ||
| Mice | RO5166017 | Attenuation of cocaine-induced hyperlocomotion | (Revel et al., 2011l) | ||
| Mice | RO5166017+ DAT−/− | Attenuation of DAT−/−-induced hyperlocomotion | (Revel et al., 2011l) | ||
| Mice | RO5166017+ DAT−/−/ Taar−/− | No effect on hyperlocomotion | (Revel et al., 2011l) | ||
| Rats | RO5073012 | Attenuation of cocaine-induced hyperlocomotion | (Galley et al., 2012) | ||
| Mice | RO5166017 | Attenuation of cocaine-induced hyperlocomotion | (Revel et al., 2011l) | ||
| Mice | RO5166017+ Taar−/− | No effect on cocaine-induced hyperlocomotion | (Revel et al., 2011l) | ||
| Mice | RO5166017+ DAT−/− | Attenuation of DAT−/−-induced hyperlocomotion | (Revel et al., 2011a) | ||
| Mice | RO5166017 | Enhancement of climbing induced by co-activation of D1 and D2 dopamine receptor | (Sukhanov et al., 2014) | ||
| Mice | RO5256390 | Attenuation of cocaine, PCP, and L-687,414- induced hyperlocomotion | (Revel et al., 2013) | ||
| Mice | RO5263397 | Attenuation of cocaine, PCP, and L-687,414- induced hyperlocomotion | (Revel et al., 2013) | ||
| Mice | RO5203648 | Attenuation of cocaine-induced hyperlocomotion | (Revel et al., 2012i) | ||
| Rats | RO5203648 | Attenuation of cocaine-induced hyperlocomotion | (Revel et al., 2012i) |