Table 3.
Demographic and SES characteristics of OPC patients by tumor HPV status determined by p16 expression and ISH with or without PCR and by smoking status (N=356)a
| All patients | HPV-positive patients | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | HPV-positive (N=315) |
HPV-negative (N=41) |
p | Crude OR (95% CI) |
Adjusted OR (95% CI)b |
Never/light smokers (N=175) |
Smokers (N=101) |
p | Crude OR (95% CI) |
Adjusted OR (95% CI)b |
| Age, years | .313 | .001 | ||||||||
| ≤55 | 157 (49.8) | 17 (41.5) | 1.0 | 1.0 | 93 (53.1) | 45 (44.6) | 1.0 | 1.0 | ||
| >55 | 158 (50.2) | 24 (58.4) | 0.7 (0.4–1.4) | 0.7 (0.3–1.6) | 82 (46.9) | 56 (55.5) | 0.7 (0.4–1.2) | 0.7 (0.4–1.2) | ||
| Median (IQR) | 56 (50–62) | 58 (51–64) | ||||||||
| Sex | .001 | .051 | ||||||||
| Male | 276 (87.6) | 28 (68.3) | 1.0 | 1.0 | 149 (85.1) | 94 (93.1) | 1.0 | 1.0 | ||
| Female | 39 (12.4) | 13 (31.7) | 0.3 (0.1–0.6) | 0.2 (0.1–0.6) | 26 (14.9) | 7 (6.9) | 2.3 (1.0–5.6) | 3.7 (1.3–11.1) | ||
| Ethnicity | .034 | .525 | ||||||||
| White | 287 (91.1) | 33 (80.5) | 1.0 | 1.0 | 160 (91.4) | 90 (89.1) | 1.0 | 1.0 | ||
| Other | 28 (8.9) | 8 (19.5) | 0.4 (0.2–1.0) | 0.5 (0.2–1.4) | 15 (8.6) | 11 (10.9) | 0.8 (0.3–1.7) | 0.8 (0.3–2.0) | ||
| Marital status | .043 | .176 | ||||||||
| Currently married | 218 (79.6) | 24 (64.9) | 1.0 | 1.0 | 142 (82.1) | 76 (75.3) | 1.0 | 1.0 | ||
| Never/formerly married | 56 (20.4) | 13 (35.1) | 0.5 (0.2–1.0) | 0.8 (0.3–2.0) | 31 (17.9) | 25 (24.8) | 0.7 (0.4–1.2) | 0.7 (0.3–1.5) | ||
| Missing | 41 | 4 | 2 | 0 | ||||||
| Income/year | .052 | .005 | ||||||||
| <$50,000 | 55 (21.4) | 13 (38.2) | 1.0 | 1.0 | 25 (15.2) | 30 (32.3) | 1.0 | 1.0 | ||
| $50,000–$99,999 | 79 (30.7) | 11 (32.4) | 1.7 (0.7–4.1) | 0.9 (0.3–2.6) | 52 (31.7) | 27 (29.0) | 2.3 (1.1–4.7) | 1.6 (0.7–3.6) | ||
| ≥$100,000 | 123 (47.9) | 10 (29.4) | 2.9 (1.2–7.0) | 1.3 (0.4–4.2) | 87 (53.1) | 36 (38.7) | 2.9 (1.5–5.6) | 1.4 (0.6–3.0) | ||
| Missing | 58 | 7 | .600c | 11 | 8 | .575c | ||||
| Education level | .002 | <.001 | ||||||||
| High school or GED or less | 65 (23.7) | 19 (51.4) | 1.0 | 1.0 | 25 (14.5) | 40 (39.6) | 1.0 | 1.0 | ||
| Technical or vocational school | 85 (31.0) | 6 (16.2) | 4.1 (1.6–11.0) | 2.8 (1.0–8.4) | 52 (30.1) | 33 (32.7) | 2.5 (1.3–4.9) | 2.0 (1.0–4.1) | ||
| Bachelor’s degree or greater | 124 (45.3) | 12 (32.4) | 3.0 (1.4–6.6) | 1.2 (0.4–3.2) | 96 (55.5) | 28 (27.7) | 5.5 (2.9–10.5) | 5.2 (2.5–10.8) | ||
| Missing | 41 | 4 | .638c | 2 | 0 | <.001c | ||||
| SES composite | .003 | <.001 | ||||||||
| Q1 (low) | 65 (25.3) | 18 (52.9) | 1.0 | 1.0 | 27 (16.5) | 38 (40.9) | 1.0 | 1.0 | ||
| Q2 (mid) | 104 (40.5) | 7 (20.6) | 4.1 (1.6–10.4) | 2.6 (1.0–7.0) | 67 (40.9) | 37 (39.8) | 2.5 (1.3–4.8) | 2.4 (1.2–4.7) | ||
| Q3 (high) | 88 (34.2) | 9 (26.5) | 2.7 (1.1–6.4) | 1.1 (0.4–3.0) | 70 (42.7) | 18 (19.4) | 5.5 (2.7–11.2) | 5.3 (2.5–11.3) | ||
| Missing | 58 | 7 | .672c | 11 | 8 | <.001c | ||||
GED, graduate equivalency degree; IQR, interquartile range.
a
Values in table are number of patients (%) unless otherwise indicated.
b
Adjusted for all other variables and pack years of smoking (SES composite not adjusted for income/education level).
c
P for trend.