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Representative histology of transplanted hearts from allograft recipients on post-transplant day 28. The first panel shows diffuse leukocyte infiltration in an untreated animal (ISHLT Grade 3R), the second panel shows minimal leukocytic infiltrate in an animal treated with anti-CD40L (Grade 1R), and the third panel shows interstitial leukocytic infiltrate in an animal treated with low dose rapamycin (Grade 3R).
