Skip to main content
. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Biol Psychiatry. 2015 Feb 11;78(12):848–859. doi: 10.1016/j.biopsych.2015.02.004

Figure 7. Proposed working model depicting activity-dependent regulation of Gomafu lncRNA in the mouse prefrontal cortex.

Figure 7

Under basal conditions, Gomafu lncRNA associates with the PRC1 (BMI1) complex to mediate in cis repression of Crybb1, potentially through the histone ubiquitination mark. In response to an environmental stimulus, such as that triggered by the fear-conditioning paradigm, Gomafu lncRNA is significantly down-regulated, rapidly releasing BMI1 from the Crybb1 promoter and allowing its transcription, resulting in the up-regulation of Crybb1.