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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Addict Biol. 2015 Feb 11;21(4):939–953. doi: 10.1111/adb.12232

Figure 1. Graphical representation of the adolescent intermittent ethanol (AIE) treatment paradigm.

Figure 1

Rats received either ethanol (5.0 g/kg, 20% ethanol w/v, i.g.) or a comparable volume of water from postnatal day (P)25 to P55 on a 2-day on/2-day off administration schedule. Blood ethanol concentrations (BECs) were assessed one hr after ethanol exposure on P38 and P54. Subjects in the first age group were sacrificed on P80 for diffusion tensor imaging (DTI) analysis. Subjects in the second age group were behaviorally tested on the open-field object recognition task from P163 to P165 and on the light/dark box anxiety test on P219. The subjects were then sacrificed on P220 for DTI analysis.