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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2015 Feb 11;136(3):757–768. doi: 10.1016/j.jaci.2014.12.1936

Figure 3. HVEM and LTβR participate in promoting lung fibrotic activity induced by bleomycin and recombinant LIGHT.

Figure 3

WT mice were compared to mice treated with 200 μg neutralizing anti-LTβR and to HVEM−/− mice. (a) Mice were treated with 10μg rmLIGHT intratracheally on days 1 and 2 before sacrificing on day 3. (b) Mice were treated with bleomycin intratracheally and sacrificed on day 7. Fibrotic phenotypes were assessed as before in the lungs. Trichrome data show mean ratio of AOI values over PBS of 4 individual mice per condition. aSMA data show values of 10 (a) to 35 (b) random bronchi scored from 4 mice per condition. Results are representative of 3 experiments performed.