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Affinity profiles (IC50) of somatostatin receptor subtypes for different somatostatin analogs used in diagnostic imaging and therapy
| sst1 | sst2 | sst3 | sst4 | sst5 | |
|---|---|---|---|---|---|
| Somatostatin-28 | 5.2 | 2.7 | 7.7 | 5.6 | 4.0 |
| 111In-octreotide | >10,000 | 22 | 182 | >1000 | 237 |
| 68Ga-DOTATOC | >10,000 | 2.5 | 613 | >1000 | 73 |
| 68Ga-DOTANOC | >10,000 | 1.9 | 40 | 260 | 7.2 |
| 68Ga-DOTATATE | >10,000 | 0.2 | >1000 | 300 | 377 |
IC50 is expressed in nanomoles (lower values represent higher receptor affinity)
