Table 1.
Mean count densities of FR-positive KB tumor and non-target organs measured on serial scintigraphy after injection of 99mTc-ECG-EDA-folate with or without pre-administration of excess free folate
| Organ | Time after injection | MCD* (mean ± SD) | P value† | |
|---|---|---|---|---|
| in vivo imaging study (n = 2) |
in vivo inhibition study (n = 3) |
|||
| KB tumor | 30 min | 3.93 ± 0.82 | 2.77 ± 0.52 | 0.248 |
| 1 h | 3.82 ± 0.50 | 2.31 ± 0.73 | 0.083 | |
| 2 h | 3.52 ± 0.17 | 2.06 ± 0.66 | 0.083 | |
| 4 h | 3.12 ± 0.06 | 1.56 ± 0.51 | 0.083 | |
| Muscle | 30 min | 1.03 ± 0.05 | 1.04 ± 0.26 | 0.564 |
| 1 h | 0.62 ± 0.10 | 0.66 ± 0.23 | 0.767 | |
| 2 h | 0.46 ± 0.04 | 0.48 ± 0.19 | 0.767 | |
| 4 h | 0.23 ± 0.02 | 0.34 ± 0.16 | 0.564 | |
| Blood | 30 min | 4.39 ± 0.25 | 4.16 ± 0.99 | 0.767 |
| 1 h | 2.62 ± 0.21 | 3.01 ± 1.29 | 0.564 | |
| 2 h | 1.92 ± 0.11 | 2.01 ± 0.94 | 1.000 | |
| 4 h | 1.35 ± 0.10 | 1.41 ± 0.62 | 0.564 | |
| Liver | 30 min | 6.04 ± 0.93 | 4.63 ± 1.24 | 0.564 |
| 1 h | 4.81 ± 0.72 | 3.63 ± 1.46 | 0.248 | |
| 2 h | 3.64 ± 0.27 | 2.89 ± 1.11 | 0.564 | |
| 4 h | 3.02 ± 0.10 | 2.48 ± 0.83 | 0.767 | |
* decay corrected, normalized by injection dose and acquisition time (counts/pixel per 37 MBq of injection dose and 1 min acquisition time)
† P values of Mann–Whitney U test