Prevalence of steatohepatitis is increasing worldwide. Patients with obesity, type 2 diabetes (T2DM), and insulin resistance are specifically affected.

There is no approved drug for the treatment of NASH but there are a wide variety of compounds with different modes of actions currently in clinical development.

The ideal treatment is expected, in the short term, to reduce liver inflammation and fibrosis, and improve insulin sensitivity and metabolic complications; however, in the long term, a benefit in reducing cardiovascular and hepatic outcomes will need to be demonstrated.