Table 5.
Tumors inconsistent with World Health Organization 2003 leiomyosarcoma criteria
| Author/date type | Leiomyoma sub-type | Age (years) | Pathology | Recurrence |
|---|---|---|---|---|
| ∞Leibsohn/1990 retro | Atypical | 36 | 6 mitoses/10 HPF, “poorly demarcated,” cellular atypia | NED 6 months |
| Atypical | 48 | 7 mitoses/10 HPF, cellular atypia | NED 16 months | |
| ∞Parker/1994 retro | Atypical | 30 | Irregular infiltrative borders, mild nuclear atypia, 5–8 mitoses/10 HPF | NED “years” |
| Seki/1992 retro | Mitotically active | 33 | 6 mitoses/10 HPF, no cellular atypia | NED 11 months |
| Mitotically active | 34 | 5 mitoses/10 HPF, no cellular atypia | NED 57 months | |
| Mitotically active | 43 | 8 mitoses/10 HPF, no cellular atypia | NED 61 months | |
| Mitotically active | 43 | 9 mitoses/10 HPF, no cellular atypia | NED 72 months |
HPF high-powered field
Retro retrospective
∞ included in FDA analysis
NED no evidence of disease