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. 2015 Jun 15;7(6):1181–1188.

Figure 2.

Figure 2

Monoclonal Antibody 9-8B Inhibits Enzymatic Activity of CD39. A. Flow-cytometric analysis shows inhibition of ADP-induced platelet aggregation by 9-8B (4 μM) and POM-1 (10 μM). Naïve; untreated platelets, -; rhCD39 (2 μM)+ ATP (1 mM) treated platelets. B. Orthogonal radioactive CD39 assay demonstrates inhibition of ATPase activity on IGN-SRC-004 cells by 9-8B (6 nM) and POM-1 (10 μM). Ectonucleotidase activity is expressed as picomolar of hydrolyzed free 33Pi per minute per 1000 cells. ***P < 0.001.