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. 2015 Aug 12;35(32):11374–11383. doi: 10.1523/JNEUROSCI.1163-15.2015

Figure 1.

Figure 1.

Co-upregualtion of APP and Nebula rescues APP-induced STM and LTM impairments. A, Aversive associative memory performance of 2- to 4-d-old flies 3 min after training (STM) for the indicated genotypes. n = 18 trials per genotype, *p < 0.05 compared with control and the indicated genotypes. B, Memory deficits not attributed to differences in APP expression. Western blot depicting equivalent levels of APP in the genotypes with APP upregulation driven by the C739–GAL4, a mushroom body-specific driver. APP levels were normalized to control and tubulin. n = 3 independent experiments. C, Quantification of memory performance immediately and 24 h after spaced training (LTM). n = 6 trials per genotype, *p < 0.05 comparing the indicated genotypes. D, Representative confocal stack images of brains dissected from 2- to 4-d-old flies and stained with Fasciclin II antibody. The area analyzed is highlighted (α and β lobes). There is no change in the gross mushroom body (MB) structure or size across genotypes. n > 6 brains per genotype. Scale bar, 50 μm. All values indicate mean ± SEM.