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. 2015 Aug 12;35(32):11374–11383. doi: 10.1523/JNEUROSCI.1163-15.2015

Figure 2.

Figure 2.

APP-mediated impairments in STM are rescued by restoring calcineurin or PKA activity. (A) STM performance index for 2–4 d-old flies of the indicated genotypes. n = 18 trials. B, PKA activity compared across genotypes. Quantification represents assays normalized to the control. n = 12 independent experiments. C, Western blot analysis of phosphorylated CREB levels using nuclear extracts prepared from 2- to 4-d-old flies. Co-upregulation of APP and Nebula restored phosphorylated CREB levels to that of the control. The nuclear TATA binding protein (TBP) was used as a loading control. n = 8 independent experiments. All values are mean ± SEM. *p < 0.05 compared with control and the indicated genotypes.