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In vivo Tat expression leads to decreased MBP and MAG. Western blot analysis of tissue lysate from transgenic mice after 3 month Tat induction showed decreased levels of both MBP and MAG. Protein expression was normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH; n = 4; values are mean ± SEM; *p < 0.05, t test).
