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. 2015 Jul 29;2015:508342. doi: 10.1155/2015/508342

Figure 5.

Figure 5

Effect of pentamidine (0.05–5 μg/mL/day) on GFAP and p53 expression in astrocyte in the hippocampi of Aβ-injected mice. (a) Immunofluorescence analysis of hippocampal coronal sections. Note the increased GFAP expression in hippocampal astrocytes of Aβ-treated (2) compared to vehicle-treated mice (1) and the dose-dependent reduction after pentamidine treatment (3-4-5). Scale bar: 50 μm. (b) Relative quantification of p53-positive/GFAP-positive (open bars) and p53-positive/GFAP-positive (filled bars) astrocytes in the CA1 area of the brain. Results are expressed as mean ± SEM of n = 4 experiments performed in triplicate. ∗∗∗ P < 0.001 versus vehicle-treated mice; °P < 0.05 and °°°P < 0.001 versus Aβ-treated mice. §§ P < 0.01 versus vehicle-treated mice; ## P < 0.01, ### P < 0.001 versus Aβ-treated mice.