Table 6.
The effect of test compounds on survival time of EAC cell bearing mice.
| Days | Control (EAC) | Bleomycin (0.3 mg/kg i.p.) |
DMSO 25 mg/kg |
A 8 mg/kg |
B 10 mg/kg |
C 16 mg/kg |
|---|---|---|---|---|---|---|
| 0 | 00 | 00 | 00 | 00 | 00 | 00 |
| 2 | 0.77 ± 0.37 | 0.57 ± 0.17 | 0.76 ± 0.38 | 0.55 ± 0.13 | 0.64 ± 0.19 | 0.60 ± 0.26 |
| 4 | 0.98 ± 0.43 | 0.75 ± 0.22 | 0.97 ± 0.63 | 0.72 ± 0.22 | 0.84 ± 0.24 | 0.82 ± 0.17 |
| 6 | 1.30 ± 0.27 | 1.10 ± 0.24 | 1.31 ± 0.33 | 1.06 ± 0.24 | 1.21 ± 0.16 | 1.16 ± 0.31 |
| 8 | 1.54 ± 0.32 | 1.24 ± 0.14 | 1.57 ± 0.23 | 1.14 ± 0.12 | 1.37 ± 0.16 | 1.31 ± 0.14 |
| 10 | 1.78 ± 0.18 | 1.44 ± 0.30 | 1.76 ± 0.16 | 1.29 ± 0.19 | 1.48 ± 0.26 | 1.43 ± 0.22 |
| 12 | 2.13 ± 0.17 | 1.63 ± 0.16 | 2.14 ± 0.17 | 1.47 ± 0.22 | 1.77 ± 0.18 | 1.71 ± 0.14 |
| 14 | 2.55 ± 0.67 | 1.80 ± 0.23 | 2.55 ± 0.63 | 1.73 ± 0.32 | 1.93 ± 0.34 | 1.84 ± 0.18 |
| 16 | 3.94 ± 0.55 | 2.05 ± 0.27 | 3.93 ± 0.53 | 1.94 ± 0.14 | 2.17 ± 0.12 | 2.10 ± 0.21 |
| 18 | 4.44 ± 0.43 | 2.20 ± 0.15 | 4.40 ± 0.42 | 2.13 ± 0.12 | 2.47 ± 0.15 | 2.29 ± 0.23 |
| 20 | 5.13 ± 0.63 | 2.43 ± 0.11 | 5.14 ± 0.62 | 2.36 ± 0.16 | 2.73 | 2.49 ± 0.44 |
A = K[Cu(SB-1)(SCN)], B = [Cu(SB-2)NN], NN = 2-aminopyridine, and C = [Cu(SB-2)(NN)], NN = 2-phenylenediamine.