Table 2.
Comparison of characteristics and hs-CRP in 3 subgroups of AD and healthy controls
| Group I | Group II | Group III | HC | P-value | Post-hoc analysis | |
|---|---|---|---|---|---|---|
| Number of subjects | 85 | 275 | 168 | 319 | - | - |
| Age | 63.28±5.93 | 74.77±2.86 | 84.04±4.42 | 74.47±9.4 | <0.001 | I<II=HC<III |
| Gender, male | 32 | 103 | 66 | 137 | 0.184 | I=II=III=HC |
| hs-CRP (mg/dl)* | 4.67±11.96 | 4.19±14.81 | 2.25±4.70 | 0.39±0.97 | <0.001 | I=II=III>HC |
| MMSE | 19.29±5.24 | 17.91±5.53 | 16.32±5.87 | 28.86±1.19 | <0.001 | I<II<III<HC |
| CDR | 0.86±0.61 | 0.81±0.58 | 1.02±0.73 | - | <0.001 | I=II<III |
| SOB | 4.29±3.81 | 4.14±3.63 | 5.61±4.66 | - | <0.001 | I=II<III |
| GDS | 3.81±0.93 | 3.83±0.99 | 4.18±1.19 | - | <0.001 | I=II<III |
AD: Alzheimer's disease, HC; Healthy control group, hs-CRP; high-sensitivity C-reactive protein, Group I, less than 70-year-old; Group II, 70-year-old to 79-year-old; Group III, more than 80-year-old. MMSE: Mini-mental State Examination, CDR: Clinical Dementia Scale, SOB: the Sum of the Box score of the CDR, GDS:Global Deterioration Scale
Values was expressed as mean ± standard deviation
Comparison of Gender was analyzed by Pearson chi-square test among 3 AD subgroups and healthy controls
* P-value was calculated by using covariance analysis for MMSE and Age