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. 2015 Aug 12;3:51. doi: 10.3389/fchem.2015.00051

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Copyright © 2015 Liu, Yuan, Fales, Register and Vo-Dinh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) TEM images of synthesized AuNS (left), silica-coated AuNS (middle), and silver coated-AuNS (right). (B) CT (left) and MRI (right) imaging with developed multifunctional AuNS nanoprobe. (C) Demonstration of TAT-peptide enhanced TPL imaging, photodynamic therapy (PDT), and surface-enhanced Raman scattering (SERS) imaging after 1-h incubation with the AuNS probe. Scale bars for TPL, PDT and SERS image are 10, 250, and 20 μm, respectively. (D) PET/CT imaging with ⁶⁴Cu labeled AuNS probe, which was injected intravenously through tail vein. Dynamic imaging at various time pointes were acquired. Arrow shows tumor (Fales et al., 2011, 2013, 2014; Yuan et al., 2013a; Liu et al., 2015b).