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. 2015 Aug 12;5:12999. doi: 10.1038/srep12999

Figure 2. Immunohistochemistry staining of EZH2 in human osteosarcoma tissues.

Figure 2

(A) Representative images of EZH2 expression (200×) in osteosarcoma and osteoblastoma. EZH2 expression is notably higher in osteosarcoma than osteoblastoma. In osteoblastoma, although some of the inflammatory cells and surrounding red cells showed nuclear staining of EZH2, the osteoblasts are absent of EZH2 expression (indicated by arrows). Quantitative comparison of EZH2 expression between osteosarcoma and osteoblastoma, p < 0.01 (right). (B) Representative images of EZH2 expression in high-grade and low-grade osteosarcoma. EZH2 expression is higher in high-grade osteosarcoma than low-grade. Quantitative comparison of EZH2 expression between high-grade and low-grade osteosarcoma, p < 0.01 (right). (C) Representative images of EZH2 expression in osteosarcoma with or without metastasis. EZH2 is higher in osteosarcoma with metastasis than without metastasis. Quantitative comparison of EZH2 expression between osteosarcoma with or without metastasis, p < 0.01 (right). Scale bars: 50 μm.