. 2015 Aug 1;31(8):783–791. doi: 10.1089/aid.2014.0370

Table 2.

Infant Viral Load (Copies/ml) and Type of Resistance Mutations Among Infants Who Developed Resistance

PTID	Parameter	Enrollment	Month 1	Month 3	Month 6	Month 9	Month 12
03-0011	VL c/ml	No sample	94,400	208,800	559,400	569,200	166,600
	R/Mut	No sample	None	K103N	K103N	K103N	K103N
				M184V	M184V	M184V	M184V
03-0015	VL c/ml	3,421,150	52,285	4,470	358,140	1,228,500	2,056,800
	R/Mut	None	None	None	Y181C	Y181C	Y181C
					A98AG	A98G	A98G
					M184V	M184V	M184V
TAMs							K70KR
							D67DN
							T215NSTY
03-0025	VL c/ml	4,996,750	10,825	10,780,500	99,315	219,725	101,995
	R/Mut	None	None	None	Y188L	Y188L	Y188L
					M184V	M184V	M184V
03-0043	VL c/ml	7,883,300	152,045	36,200	1,262,000	608,500	994,500
	R/Mut	None	None	None	Y188L	None	Y188^*FLY
							M184MV
					D67DG		T215I
TAMs					K70R		D67DN
							K70KR
							K219EK
03-0045^a	VL c/ml	17,734,500	88,290	16,175	412,230	170,190	1,045,600
	R/Mut	None	None	None	Y181C	Y181C	Y181C
					D67G	D67G	D67DG
					M184V	M184V	M184V
03-0054	VL c/ml	1,2466,650	1,580	885	1,704,500	695,600	168,115
	R/Mut	None	None	—	K103N	K103N	K103N
						M184IMV	M184IMV
03-0075^b	VL c/ml	164,200	4,260	690	320	19,385	No sample
	R/Mut	None	None	—	G190A	G190A	No sample
					K65R	K65KR
						M184MV
TAMs					M41LM	D67DN

^{^a}

The mother of this infant was on ARVs at enrollment, but the regimen could not be ascertained.

^{^b}

One infant had initial first detected sample at month 9; however, this subject had a sample from an earlier time point with viral load<1,000 copies/ml and resistance detected, and so the timing of first detection was considered as month 6.

All seven infants had additional M184V (NRTI) mutations; this confers high-level resistance to lamivudine (3TC) and emtricitabine (FTC), but increases susceptibility to zidovudine (AZT) and tenofovir (TDF).

Note: refer to Supplementary Table S1 for infant viral load (copies/ml) and PCR amplification among infants who did not develop resistance.

Bold: sample was unavailable.

Italics: HIV-1 plasma viral load<1,000 copies/ml and resistance testing not performed.