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Schematics for theory-driven functional magnetic resonance imaging (fMRI). Recorded data (top) evoke preliminary models of brain function in various research areas. An explicit, physiologically meaningful mathematical model (center) can be modified according to hypotheses and can simulate nonexistent data. This prediction can be compared with new experimental data to validate or confront the hypotheses. The high-contrast boxes indicate areas that are most relevant for the fMRI.
