Table 1.
Serotonin EC50s (μM) and Imaxs Derived from Serotonin Concentration-Response Curves Obtained in the Absence (Control) or Presence of Anesthetics and n-Alcohols
| Control | +Anesthetic or n-alcohol | EC50 Cntrl/EC50 test | |
|---|---|---|---|
| Chloroform | |||
| EC50 | 2.32 ± 0.20 | 1.07 ± 0.11 | 2.2 |
| Imax | 101 ± 4.92 | 91.4 ± 4.05 | |
| Sevoflurane | |||
| EC50 | 2.94 ± 0.06 | 3.74 ± 0.26 | 0.79 |
| Imax | 100 ± 1.06 | 44.6 ± 1.35 | |
| Isoflurane | |||
| EC50 (2 × MAC) | 2.09 ± 0.15 | 2.09 ± .04 | 1 |
| Imax | 96.9 ± 0.5 | 89.5 ± 1.06 | |
| Isoflurane | |||
| EC50 (4 × MAC) | 2.45 ± 0.08 | 1.72 ± .08 | 1.4 |
| Imax | 96.5 ± 1.83 | 50.7 ± 1.3 | |
| Butanol | |||
| EC50 | 1.71 ± .07 | 0.85 ± 0.11 | 2 |
| Imax | 97.6 ± 2.02 | 75.6 ± 4.2 | |
| Octanol | |||
| EC50 | 1.95 ± 0.02 | 2.52 ± 0.04 | 0.77 |
| Imax | 93.5 ± 0.49 | 31.9 ± 0.25 | |
| Pentanol | |||
| EC50 | 1.97 ± 0.07 | 1.30 ± 0.09 | 1.5 |
| Imax | 99.7 ± 1.88 | 75.0 ± 2.43 | |
| Hexanol | |||
| EC50 | 2.16 ± 0.12 | 2.72 ± 0.13 | 0.79 |
| Imax | 97.9 ± 3.11 | 64.3 ± 2.31 | |
MAC = minimum alveolar concentration; EC50 = serotonin concentration that produces a half-maximal current response; Imax = maximal current evoked by high serotonin concentrations (expressed as a percent of control).