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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Ann Surg. 2015 Sep;262(3):476–485. doi: 10.1097/SLA.0000000000001427

Table 2.

Predictors of overall survival analysis in all patients (n=2368).

Characteristics N (%) Overall survival Univariate Multivariate
5YS, % Median, months HR (95% CI) P HR (95% CI) P
Age, years 2368 (100%) 43 50.6 1.01 (1.01–1.02) <0.001 1.01 (1.004–1.015) <0.001
Gender 0.96 (0.87–1.07) 0.5 NA NA
 Female 1018 (43%) 42 50
 Male 1350 (57%) 44 52
Solitary tumor 0.8 (0.7–0.9) 0.001 0.8 (0.7–0.9) <0.001
 Yes 1010 (43%) 49 59
 No 1358 (57%) 39 45
Size 1.6 (1.4–1.7) <0.001 1.4 (1.2–1.6) <0.001
 <5 cm 1654 (70%) 47 56
 ≥5 cm 714 (30%) 33 38
CEA 1.7 (1.4–2) <0.001 1.3 (1.1–1.6) 0.009
 <200 μg/L 1950 (92%) 45 53
 ≥200 μg/L 178 (8%) 27 35
Nodal status of primary 1.4 (1.3–1.6) <0.001 1.6 (1.4–1.7) <0.001
 Negative 907 (39%) 51 63
 Positive 1440 (61%) 38 45
Disease-free interval (DFI) 0.99 (0.9–1.1) 0.9 NA NA
 <12 months 1504 (64%) 42 50
 >12 months 864 (36%) 45 52
Presentation sequence 0.98 (0.9–1.1) 0.8 NA NA
 Metachronus 1187 (50%) 44 50
 Synchronous 1181 (50%) 42 50
Clinical risk score (CRS) 1.5 (1.3–1.6) <0.001 NA NA
 <3 1129 (53%) 51 62
 ≥3 987 (47%) 36 42
Margin status1 <0.001 <0.001
 0mm 245 (10%) 24 32 Ref Ref Ref Ref
 0.1mm–0.9mm 160 (7%) 26 40 0.7 (0.6–0.9) 0.04 0.7 (0.6–0.9) 0.03
 1mm–9mm 1191 (50%) 46 53 0.5 (0.4–0.6) <0.001 0.6 (0.5–0.7) <0.001
 ≥10mm 765 (33%) 48 56 0.5 (0.4–0.6) <0.001 0.5 (0.4–0.6) <0.001
Perioperative chemotherapy 0.8 (0.6–0.9) 0.01 NA NA
 No 172 (7%) 36 41
 Yes 2193 (93%) 43 51
Perioperative modern chemotherapy 0.75 (0.7–0.8) <0.001 NS NS
 No 879 (38%) 38 45
 Yes 1442 (62%) 46 54
Operation period 0.7 (0.6–0.8) <0.001 0.8 (0.7–0.9) <0.001
 <2004 1177 (50%) 39 44
 ≥2004 1191 (50%) 47 56
Extrahepatic disease (EHD) 1.7 (1.4–2.0) <0.001 1.6 (1.3–1.9) <0.001
 No 2173 (92%) 45 52
 Yes 195 (8%) 25 33
HAIP 0.65 (0.6–0.7) <0.001 0.7 (0.6–0.8) <0.001
 No 1534 (65%) 37 44
 Yes 834 (35%) 53 67
Ablation 1.02 (0.8–1.2) 0.9 NA NA
 No 2134 (90%) 43 51
 Yes 234 (10%) 38 45
Two-stage resection 1.02 (0.7–1.5) 0.9 NA NA
 No 2316 (98%) 43 51
 Yes 52 (2%) 43 49

NA – not analyzed; NS – not significant; HAIP – hepatic artery infusion pump; CEA - carcinoembryonic antigen.

1

Seven patients had the margin recorded only as positive/negative. Thus, they were excluded from these variables.