Table III.
MIC and mutation in 23S rRNA of selected resistant isolates.
| MIC (µg/ml) | Mutation | |||||||
|---|---|---|---|---|---|---|---|---|
| Patient descriptiona | Sample date YY-MM-DD | ERY | AZM | Josamycin | 2057 | 2058 | 2059 | 2611 |
| M, 26 years, balanitis | 07-08-27 (pre treatment) | 0.5→4 | 0.5→8 | 0.04→0.32 | – | – | A→G | – |
| M, urethritis, clarithromycin and moxifloxacin treatment failure | 06-10-09 (post treatment) | 0.5→2 | 0.5→4 | 0.04→0.16 | – | – | – | – |
| M, 21 years, perineum itching | 07-05-16 (pre treatment) | 1→16 | 1→8 | 0.08→0.32 | A→G | – | – | T→C |
| M, 48 years, asymptomatic | 07-04-09 (pre treatment) | 1→4 | 0.5→4 | 0.16→0.64 | A→G | – | – | T→C |
| M, 25 years, urethritis | 07-08-04 (pre treatment) | 1→8 | 0.5→8 | 0.08→0.64 | – | – | – | – |
| F, 29 years, cervicitis | 06-11-26 (pre treatment) | 1→16 | 0.5→4 | 0.08→0.32 | – | – | – | T→C |
| F, 26 years, cervicitis | 06-11-26 (pre treatment) | 1→4 | 1→4 | 0.16→0.64 | – | – | – | T→C |
| F, 32 years, cervicitis | 06-09-05 (pre treatment) | 1→8 | 1→8 | 0.16→0.64 | – | – | – | T→C |
| M, 28 years, balanitis | 07-05-26 (pre treatment) | 1→4 | 0.5→4 | 0.04→0.16 | A→G | – | – | T→C |
| M, 56 years, balanitis | 07-06-08 (pre treatment) | 1→8 | 1→16 | 0.04→0.32 | – | – | A→G | T→C |
| M, 49 years, balanitis | 08-01-17 (pre treatment) | 1→16 | 0.5→4 | 0.08→0.32 | A→G | – | – | T→C |
| M, 49 years, balanitis | 08-01-17 (pre treatment) | 0.5→4 | 0.5→2 | 0.08→0.32 | A→G | – | – | T→C |
| F, 27 years, cervicitis | 08-02-01 (pre treatment) | 0.5→4 | 0.5→4 | 0.04→0.16 | A→G | – | – | T→C |
a
All serovar E; M, male; F, female; MIC, minimum inhibitory concentration; ERY, erythromycin; AZM, azithromycin.