Table II.
Tumor volume of colorectal cancer specimens.
| Fucoxanthin | Fucoxanthinol | Fluorouracil | Paclitaxel | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Specimen | 5 µM | 10 µM | 20 µM | 5 µM | 10 µM | 20 µM | 1.0 µg/ml | 1.0 µg/ml | Resected tissue |
| 1 | 105.4±8.7 | 96.5±3.3 | 62.6±9.2 | 77.0±9.5 | 22.9±3.9b | 1.5±0.3a | 104.3±2.1 | – | Rectum |
| 2 | 91.6±11.3 | 56.0±10.8 | 16.5±2.2 | 90.9±8.2 | 9.2±1.3a | 7.1±0.6a | 85.7±12.6 | 75.8±6.5 | Rectum |
| 3 | – | – | – | 67.9±7.0 | 11.8±0.8 | 7.2±0.8 | 109.2±5.2 | 126.6±5.2 | Ascending colon |
| 4 | 106.7±7.5 | 92.7±5.6 | 77.4±10.4 | 108.5±12.1 | 57.9±3.1a | 7.2±0.9a | 92.8±3.4 | 100.3±7.7 | Rectum |
| 5 | 151.7±11.5 | 154.7±13.6 | 136.9±2.5 | 143.7±13.1 | 87.3±4.4a | 12.9±1.8b | 78.1±6.0 | 87.4±5.2 | Rectum |
| 6 | – | – | – | 73.1±5.3 | 41.1±11.3 | 18.2±0.3 | 58.8±9.8 | 20.1±1.4 | Rectum |
| 7 | 90.0±2.1 | 85.1±5.6 | 65.9±0.8 | 103.4±3.9a | 56.4±1.1a | 20.2±0.5b | 77.1±4.2 | 27.6±1.0 | Sigmoid colon |
| 8 | 82.0±6.9 | 92.1±12.5 | 83.6±0.6 | 81.5±0.9 | 51.1±5.0a | 21.5±2.8b | 84.3±0.5 | 66.1±5.6 | Rectum |
| 9 | 169.4±8.2 | 136.2±3.2 | 137.8±11.6 | 161.0±19.3 | 110.7±13.2 | 23.0±1.7a | 105.8±3.6 | 80.5±4.7 | Descending colon |
| 10 | – | – | – | 112.4±2.4 | 93.7±0.8 | 30.2±4.1 | 85.6±4.3 | 76.9±3.7 | Sigmoid colon |
| 11 | 76.7±7.8 | 53.6±0.8 | 46.1±13.2 | 67.7±12.6 | 24.8±7.8 | 40.0±10.0 | 52.3±6.8 | 39.9±13.4 | Transverse colon |
| 12 | 85.3±4.3 | 83.8±10.1 | 52.3±2.6 | 88.0±1.8 | 63.2±4.6 | 41.2±4.2 | 69.4±1.4 | 42.4±4.8 | Sigmoid colon |
| 13 | – | – | – | 116.8±1.1 | 72.0±4.1 | 43.0±5.6 | 83.7±1.5 | 97.5±3.0 | Rectum |
| 14 | – | – | – | 121.3±14.1 | 100.1±1.0 | 63.9±6.3 | 78.4±0.4 | 50.0±2.1 | Ascending colon |
| 15 | 106.5±4.2 | 111.2±2.5 | 85.1±5.0 | 123.0±1.5 | 112.6±4.8 | 69.8±8.5 | 104.8±3.4 | 84.1±1.8 | Descending colon |
| 16 | – | 89.9±2.9 | 77.7±4.0 | 98.8±12.7 | 92.0±7.1 | 72.9±3.8 | 113.4±5.5 | 78.0±0.3 | Ascending colon |
| 17 | – | – | – | 93.0±1.4 | 90.4±2.5 | 74.9±4.0 | 95.9±2.6 | 86.0±4.0 | Descending colon |
| 18 | 106.5±5.9 | 106.8±3.5 | 86.8±1.9 | 102.5±2.1 | 98.3±1.5 | 85.1±2.1 | 87.6±5.6 | 61.0±1.2 | Rectum |
| 19 | 100.6±6.3 | 99.6±5.3 | 99.3±4.2 | 102.5±1.4 | 100.2±2.4 | 85.4±2.3 | 98.8±3.1 | 63.8±1.3 | Ovary (Rectum origin) |
| 20 | 104.3±3.1 | 102.0±2.0 | 104.9±2.1 | 100.3±1.1 | 102.1±1.2 | 104.8±3.6 | 87.0±1.6 | 54.2±2.0 | Ascending colon |
| Median | 104.3 | 94.6 | 80.6 | 101.4 | 79.7b | 35.1b | 86.3 | 75.8 | |
Data are presented as the mean ± standard error. -, not determined.
a
Significant difference between fucoxanthin and fucoxanthinol at same dose (paired t-test, P<0.05).
b
Significant difference between fucoxanthin and fucoxanthinol at same dose (paired t-test, P<0.01).