Table 2.
Pathways Affected in the Human Fetal Liver by Maternal Smoking
| Diseases | Molecules | P-Value |
|---|---|---|
| Males | ||
| Abdominal cancer | ALDH7A1, ECHS1, EEF1B2, FTL1, HSPB1, KRT8, PDIA3, PNP, TPI1 | 3.29E-02 |
| Apoptosis | FTL1, HSPB1, KRT8, PDIA3, PNP | 2.13E-02 |
| Cellular homeostasis | FTL1, HSPB1, KRT8, PNP | 1.38E-02 |
| Genital tract cancer | ALDH7A1, EEF1B2, FTL1, HSPB1, KRT8, PDIA3 | 1.55E-02 |
| Inflammation of organ | FTL1, KRT8, PDIA3, TPI1 | 5.44E-04 |
| Lung cancer | EEF1B2, FTL1, KRT8, TPI1 | 2.00E-03 |
| Malignant neoplasm of pelvis | ECHS1, EEF1B2, FTL1, HSPB1, KRT8, PDIA3 | 1.18E-02 |
| Necrosis | FTL1, HSPB1, KRT8, PDIA3, PNP | 1.94E-02 |
| Pelvic cancer | EEF1B2, FTL1, HSPB1, KRT8, PDIA3, PNP | 2.35E-02 |
| Proliferation of cells | EEF1B2, FTL1, HSPB1, KRT8, PDIA3, PNP | 1.94E-02 |
| Quantity of cells | FTL1,HSPB1,KRT8,PNP | 1.73E-02 |
| Females | ||
| Abdominal cancer | AFP, ALDH7A1, CAT, CRYL1, ECHS1, GLUD1, HSP90AA1, KRT8, PGK1, SDHA, TPI1, USP5 | 7.88E-03 |
| Breast and colorectal cancer | AFP, CAT, CRYL1, ECHS1, HSP90AA1, KRT8, PGK1, TPI1 | 3.38E-02 |
| Digestive tract cancer | AFP, ALDH7A1, CAT, CRYL1, ECHS1, GLUD1, HSP90AA1, KRT8, PGK1, SDHA, TPI1 | 8.67E-03 |
| Epithelial cancer | AFP, ALDH7A1, CAT, ECHS1, GLUD1, HSP90AA1, KRT8, PGK1, SDHA, TPI1, USP5 | 4.16E-02 |
| Genital tract cancer | AFP, ALDH7A1, HSP90AA1, KRT8, PGK1, SDHA, USP5 | 1.87E-02 |
| Glucose metabolism disorder | CAT, ECHS1,GLUD1, KRT8 | 1.74E-02 |
| Metastasis | AFP, CAT, HSP90AA1, KRT8 | 2.27E-03 |
| Necrosis | AFP, CAT, GLUD1, HSP90AA1, KRT8, SDHA | 1.64E-02 |
| Proliferation of tumor cell lines | AFP, CAT, HSP90AA1, KRT8 | 3.07E-02 |
Disease pathways formatted in bold were dysregulated in both sexes.