Table 2.
NPEV serotypes associated with acute diarrhoea, PD, AIFoBM, PIFoBM and asymptomatic infections, and the sequence of infections in PIFoBM episodes involving EV, RV and DEC
| EV-serotypes | Strains in acute & PD episodes analysed | Frequency of detection of different NPEV serotypes in 48 independent PIFoBM-ND episodes analysed | AIFoBM-ND episodes analysed | Total IFoBM-ND samples/episodes analysed | Asymptomatic EV episodes analysed | Total EV samples/episodes examined |
|---|---|---|---|---|---|---|
| E1 | 2 |
10 (EV83, E1), (E1, 33), (E1, 11), (E32, 1, 2), (E7, 33, 1), (E1, 2), (E1, 25), (E11, 1), (E25, 25, 1, 1, 19, EPEC, RV), (E2, 1), |
10 | 20 | 10 | 32 |
| E2 | 2 | 3 (E2, 1), (E32, 1, 2), (E1, 2) | – | 3 | – | 5 |
| E3 | 2+2 | – | 1 | 1 | 1 | 6 |
| E5 | 1 | – | – | – | – | 1 |
| E6 | 5+10 |
13 (E6, 6, 6), (E6, 6, 6), (E6, 6, EPEC, RV), (E6, 6, 6), (E6, 6, 6, 6), (E21, 6, 6, OPV1), (E6, 19, 19), (E6, 19), (E6, 19, OPV1), (E11, 11, 6), (E21, 21, 6), (E11, 11, OPV1, 6, EAEC), (E19, 19, 19, 19, RV, E6, ETEC) |
3 | 16 | 2 | 33 |
| E7 | 2+8 | 2 (E7, 33, 1), (E21, 7) | 2 | 4 | 1 | 15 |
| E11 | 6+3 |
16 (E11, 11), (E11, 11), (E11, 11, 11, 11), (E11, 1), (E11, 11, 24), (E1, 11), (E25, 11), (E11, CVA9), (E32, 11), (E11, 11, 6), (E11, 11, OPV1, 6, EAEC), (E11, 11, 24, 24), (E11D, 32, OPV1), (OPV1, E11, 11), (E11D, 32, OPV1), (E11, RV) |
6 | 22 | 8 | 39 |
| E12 | – | – | – | – | 2 | 2 |
| E13 | 4+2 | 1 (E13, 13) | 1 | 2 | 1 | 9 |
| E14 | 2+1 | 4 (E14, 14), (E14, 24), (E1, 11, 14), (E14, 19), | 2 | 6 | 2 | 11 |
| E19 | 3+3 | 6 (E6,19,19), (E6, 19), (E14, 19) (E25, 25, 1, 19, 19, EPEC, RV), (E6, 19, RV, OPV1), (E19, 19, 19, 19, RV, E6, ETEC) | 3 | 9 | 5 | 20 |
| E20 | 2 | 2 (E20, 20), (E20, 33) | 2 | 4 | 3 | 9 |
| E21 | – | 3(E21, 21), (E21, 6, 6, OPV1), (E21, 21, 6) | 1 | 4 | 2 | 6 |
| E24 | 3+3 | 6 (E24, 24), (E24, 32), (E24, 32), (E11, 11, 24), (E14, 24), (E11, 11, 24, 24) | 2 | 8 | 1 | 15 |
| E25 | – | 3(E25, 25, 1, 1, 19, EPEC, RV), (E1, 25), (E25, 11) | 2 | 5 | 2 | 7 |
| E30 | 1 | – | – | – | 2 | 3 |
| E32 | 1+1 | 4 (E32, 11), (E24, 32), (E32, 1, 2) (E11, 32, OPV1) | 2 | 6 | 2 | 10 |
| E33 | 4+2 | 3 (E7, 33, 1), (E1, 33), (E20, 33) | 3 | 6 | 2 | 14 |
| EV75 | 3+2 | – | – | – | – | 5 |
| EV76 | – | – | – | – | 1 | 1 |
| EV83 | – | 1 (EV83, E1) | 1 | 2 | 1 | 3 |
| CVA4 | 1+1 | – | – | – | 1 | 3 |
| CVA9 | 1+1 | – | 1 | 1 | 1 | 4 |
| CVA13 | 1 | – | – | – | 1 | 2 |
| CVA24 | 1+1 | – | 1 | 1 | – | 3 |
| CVB3 | 2 | – | 1 | 1 | 1 | 4 |
| CVB4 | 1+2 | 1 | 1 | 1 | 5 | |
| CVB5 | 1+1 | – | – | – | – | 2 |
| OPV1 | 1+2 | 4 (OPV1, E11, 11), (E21, 6, 6, OPV1), (E11D, 32, OPV1), (E6, 19, OPV1) | – | 4 | – | 7 |
| OPV2 | 1 | – | – | – | – | 1 |
| OPV3 | 1 | – | – | – | – | 1 |
| Total | 54+45 =99 (80) | 81 (12 mono+69 sequential) (48) | 45 | 126 (91) | 53 | 278 (222) |
The numbers in each row in each column represent the number of episodes from which the VP1 gene from strains belonging to the particular EV serotype was sequenced. Strains indicated in parenthesis in italic font refer to sequential infections by more than one NPEV serotype or agent in that order and those in normal font refer to monotypic infections. Strains from all the IFoBM-ND and asymptomatic NPEV infection episodes were not examined. Numbers in italic font in the bottom row include some sequentially collected samples during persistent episodes indicating representation of some episodes more than once, and the numbers in parenthesis in normal font in the bottom row indicate actual number of PIFoBM-ND episodes analysed. In the second column, numbers in normal and italic fonts represent samples from acute and persistent diarrhoeal episodes, respectively.
AIFoBM, acute increased frequency of bowel movements; CVA, coxsackievirus A; CVB, coxsackievirus B; DEC, diarrhoeagenic Escherichia coli; E, echovirus; EAEC, enteroaggregative E. coli; EPEC, enteropathogenic E. coli; ETEC, enterotoxigenic E. coli; EV, enterovirus; IFoBM-ND, non-diarrhoeal IFoBM; NPEV, non-polio enterovirus; OPV, oral polio vaccine; PD, persistent diarrhoea; PIFoBM, persistent IFoBM; RV, rotavirus.