Table 2.
Altered expression of microRNAs related to pituitary adenomas and their target genes
| Target genes of miRNAs | Upregulated miRNAs | Downregulated miRNAs |
|---|---|---|
| AIP | miR-107 | |
| BMI1 | miR-128 | |
| E2F1 | miR-326, miR-603 | |
| HMGA1 and HMGA2 | miR-15, miR-16, miR-26a, miR-34b, miR-548c-3p, miR-196a2, let-7a | |
| HMGA2 | miR-326, miR-432, miR-570 | |
| PRKCD | miR-26a | |
| PTEN | miR-26b | |
| RARS | miR-16-1 | |
| SMAD3 | miR-135a, miR-140-5p, miR-582-3p, miR582-5p, miR-938 | |
| VEGF-R1 | miR24-1 | |
| Wee1 | miR-128a, miR-155, miR-516-3p | |
| ZAC1 | miR-26a |
AIP: aryl hydrocarbon receptor interacting protein, BMI1: BMI1 proto-oncogene, polycomb ring finger, E2F1: E2F transcription factor 1, HMGA: high mobility group A, PRKCD: protein kinase C delta, PTEN: phosphatase and tensin homolog, RARS: arginyl-tRNA synthetase, SMAD3: smad family member 3, VEGF-R1: soluble vascular endothelial growth factor receptor 1, Wee1: WEE1 G2 check point kinase, ZAC1: zinc finger regulator of apoptosis and cell cycle arrest.