Fig. 3.
A representative case of successful dose-dense temozolomide (ddTMZ) treatment after failure to standard adjuvant TMZ. A male, 64-year-old patient with multiple left parieto-temporal glioblastomas (GBMs) underwent subtotal resection of the temporal lesion, followed by radiotherapy concomitant with TMZ. After he received adjuvant TMZ for 2 cycles, the parietal lesion progressed (A–D), which was treated with 7-days on/7-days off ddTMZ, leading to shrinkage of the tumor (E, G, H) and reduction of brain edema (F). Gadolinium-enhanced T1-weighted axial (A, E), coronal (C, G), and sagittal (D, H) images and fluid-attenuated inversion recovery (FLAIR) images (B, F) taken prior to ddTMZ (A-D) and 4 months after initiation of ddTMZ (E–H) are shown.