Table 2.

Alternative dose intensified temozolomide schedules [Modified from Hegi et al.⁴⁵⁾]

ddTMZ regimens		TMZ schedule (day)		Dose intensity(mg/m2/28 days)
Standard 5/28 days	(5/28 d)		(200 mg/m2/day × 5 days/28 days)	1,000
7 days on/7 days off	(7/14 d)		(150 mg/m2/day × 7 days/14 days)	2,100
21 days on/7 days off	(21/28 d)		(100 mg/m2/day × 21 days/28 days)	2,100
Daily (continuous)	(28/28 d)		(50–100 mg/m2/day × 28 days/28 days)	1,050–2,100

ddTMZ: dose-dense temozolomide, TMZ: temozolomide.