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. 2014 Dec 20;55(1):28–37. doi: 10.2176/nmc.ra.2014-0229

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© 2015 The Japan Neurosurgical Society

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Fig. 3 — Histology of non-classic oligodendroglioma with single-positive genetic signature. A: Immunohistochemistry with isocitrate dehydrogenase (IDH)1^R132H mutation specific antibody is diffusely positive in tumor cells. B: Fluorescence in situ hybridization (FISH) study showing multiple signals of both 1p36 and 19q13 indicative of polysomy. C: Immunohistochemistry with p53 shows abundant positive cells. D: Representative H&E staining section of non-classic oligoastrocytoma. The oligodendroglial component shows round but irregular nuclei. E: The recurrent tumor 2 years after the initial resection shows marked atypia and pleomorphism corresponding to anaplastic oligoastrocytoma (H&E staining).