Table 2.
Detailed information on TRANSEURO
| Issues of criteria | Conditions |
|---|---|
| Patient selection | no cognitive impairment |
| younger than 65 years old | |
| less than 10 years of disease duration | |
| no significant L-DOPA-induced dyskinesia | |
| Tissue composition | tissue collection in several centers |
| transfer of tissue between centers (across national borders) | |
| stores up to maximum of 4 days in hibernation medium | |
| Tissue placement | standardized instrument for grafting |
| delivery of tissue through 5–7 tracts to the posterior putamen | |
| Trial design | observation study on 150 patients |
| randomized 40 patients in 150 | |
| assigned either to transplant/control group | |
| 1 year immunosuppression | |
| Primary end-point | 3 years post-transplantation |
Issues of criteria and the conditions are described, respectively. The patients are selected not to cause graft-induced dyskinesia. Tissue is collected, stored, and transplanted in a stable fashion as a guarantee for the quality of cell transplantation.