Table 1. Ca²⁺ release via IP₃R evoked by triazolophostins ^a .

Ligand	R =	pEC50	EC50 (nM)	EC50 w.r.t. 1	Max. response (%)
IP3 (1)		6.75 ± 0.08	178	1	73 ± 3
AdA (2)		8.05 ± 0.04	9	20	73 ± 2
10a	H	7.87 ± 0.00	13	13	71 ± 1
10b		7.75 ± 0.03	18	10	72 ± 2
10c		7.81 ± 0.05	15	11	65 ± 3
10d		7.77 ± 0.03	17	10	64 ± 1
10e		7.70 ± 0.07	20	9	75 ± 4
10f		8.00 ± 0.03	10	18	69 ± 1
10g		7.86 ± 0.04	14	13	71 ± 2
10h		7.64 ± 0.01	23	8	67 ± 2
10i		7.45 ± 0.03	35	5	65 ± 1
10j		7.78 ± 0.03	17	11	68 ± 2
10k		7.89 ± 0.02	13	14	70 ± 1

^aResults show the maximal Ca²⁺ release (% of Ca²⁺ content of intracellular stores), EC₅₀ and pEC₅₀ values (means ± SEM from at least 3 experiments), and EC₅₀ relative to 1 (ECIP350/ECanalog50). Hill coefficients were not significantly different from 1.