Table I.
Association of Rab25 protein and mRNA expression with clinicopathological characteristics.
| Rab25 protein, n (%) | Rab25 mRNA, n (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Patients, n (%) | Decreased | Increased | P-value | Decreased | No change | Increased | P-value | |
| Location | 0.492 | 0.976 | |||||||
| Larynx | 59 (77.6) | 23 (52.3) | 21 (47.7) | 39 (66.1) | 3 (5.1) | 17 (28.8) | |||
| Oral cavity | 9 (11.8) | 4 (57.1) | 3 (42.9) | 6 (66.7) | – | 3 (33.3) | |||
| Parotitis | 5 (6.6) | 3 (75.0) | 1 (25.0) | 4 (80.0) | – | 1 (20.0) | |||
| Paranasal sinus | 3 (3.9) | 2 (100.0) | 0 (0.0) | 2 (66.7) | – | 1 (33.3) | |||
| Stage | 0.547 | 0.411 | |||||||
| 1 | 2 (2.6) | – | – | 1 (50.0) | – | 1 (50.0) | |||
| 2 | 27 (27.6) | 12 (66.7) | 6 (33.3) | 14 (51.9) | 2 (7.4) | 4 (40.7) | |||
| 3 | 21 (35.5) | 9 (50.0) | 9 (50.0) | 17 (63.0) | – | 10 (37.0) | |||
| 4 | 26 (34.2) | 11 (52.4) | 10 (47.6) | 19 (73.1) | 1 (3.8) | 6 (23.1) | |||
| Histology | 0.384 | 0.692 | |||||||
| SCC | 67 (88.2) | 27 (54.0) | 23 (46.0) | 44 (65.7) | 3 (4.5) | 20 (29.8) | |||
| Other | 9 (11.8) | 5 (71.4) | 2 (28.6) | 7 (57.1) | – | 2 (42.9) | |||
| Local invasion | 0.126 | 0.532 | |||||||
| Negative | 18 (23.7) | 7 (77.8) | 2 (22.2) | 11 (61.1) | 1 (5.6) | 6 (33.3) | |||
| Positive | 55 (72.4) | 22 (50.0) | 22 (50.0) | 40 (72.7) | 1 (1.8) | 14 (25.5) | |||
| Age, years | 0.080 | 0.850 | |||||||
| ≥60 | 36 (47.4) | 13 (44.8) | 16 (55.2) | 25 (69.4) | 1 (2.8) | 10 (27.8) | |||
| <60 | 40 (52.6) | 19 (67.9) | 9 (32.1) | 26 (65.0) | 2 (5.0) | 12 (30.0) | |||
| Gender | 0.450 | 0.692 | |||||||
| Male | 67 (88.2) | 29 (58.0) | 21 (42.0) | 44 (65.7) | 3 (4.5) | 20 (29.8) | |||
| Female | 9 (11.8) | 3 (42.9) | 4 (57.1) | 7 (77.8) | 2 (22.2) | ||||
Rab-25, RAS-associated binding protein 25; SCC, squamous cell carcinoma; n, number.