Table 3.
Relationship between LC3B staining patterns and histopathological parameters in Group 1 (neoadjuvant-naïve) esophageal adenocarcinoma patients. Statistical analysis was carried out using chi-squared test (* p < 0. 05)
| LC3B Cytoplasmic | LC3B Globular structures | |||||
|---|---|---|---|---|---|---|
| Negative | Positive | p–value | Negative | Positive | p–value | |
| Differentiation | ||||||
| Well | 3(5.1 %) | 8(17.8 %) | 0.015* | 8(14.5 %) | 3(6.1 %) | 0.292 |
| Moderate | 29(49.2 %) | 27(60.0 %) | 30(54.5 %) | 26(53.1 %) | ||
| Poor | 27(45.8 %) | 10(22.2 %) | 17(30.9 %) | 20(40.8 %) | ||
| Tumor staging | ||||||
| Stage I | 8(13.6 %) | 9(20.0 %) | 0.001* | 12(21.8 %) | 5(10.2 %) | 0.003* |
| Stage II | 9(15.3 %) | 20(44.4 %) | 21(38.2 %) | 8(16.3 %) | ||
| Stage III-IV | 42(71.2 %) | 16(35.6 %) | 22(40.0 %) | 36(73.5 %) | ||
| Lymphatic mets | ||||||
| Negative | 11(18.6 %) | 23(51.1 %) | 0.001* | 24(43.6 %) | 10(20.4 %) | 0.013* |
| Positive | 48(81.4 %) | 22(48.9 %) | 31(56.4 %) | 39(79.6 %) | ||
| Vascular invasion | ||||||
| Negative | 34(57.6 %) | 29(64.4 %) | 0.546 | 36(65.5 %) | 27(55.1 %) | 0.319 |
| Positive | 25(42.4 %) | 16(35.6 %) | 19(34.5 %) | 22(44.9 %) | ||
| Neural invasion | ||||||
| Negative | 36(61.0 %) | 39(86.7 %) | 0.004* | 41(74.5 %) | 34(69.4 %) | 0.558 |
| Positive | 23(39.0 %) | 6(13.3 %) | 14(25.5 %) | 15(30.6 %) | ||