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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: Annu Rev Immunol. 2012 Jan 6;30:313–335. doi: 10.1146/annurev-immunol-020711-075015

Figure 3.

Figure 3

Neurons regulate innate immunity in Caenorhabditis elegans. (a) Wild-type C. elegans infected with bacterial pathogens die, but OCTR-1 knockout animals are significantly protected from lethal infection. (b) The mechanism depends on the role of OCTR-1-expressing neurons to inhibit innate gene expression required for the unfolded protein response.